Jason Kottke has put together a list of nearly fifty things you can do with your iPod including share your music with strangers, dj at a club and view your photos. Kottke says you can also podcast with the iPod:
Using a voice recorder attachment, you can record your thoughts on your iPod, dump it to your computer, publish it to your web site in such a way that people can download your musings to their iTunes Library, sync that with their iPod, and listen to you babble about something on their way to work. It's called podcasting and hopefully it'll get much easier than that.